Cannabidiol (CBD) oil is one of the hot new product in states that have legalized medical marijuana. The non-intoxicating marijuana extract is being credited with helping treat a number of medical problems — everything from epileptic seizures to anxiety to inflammation to sleeplessness. But experts say the evidence is scant for the majority of these touted benefits.
Worse, CBD will be produced without the regulation, causing products which vary widely in quality, said Marcel Bonn-Miller, an adjunct assistant professor of psychology in psychiatry on the University of Pennsylvania School of Medicine. “It is actually the Wild West,” Bonn-Miller said. “Joe Bob who starts up a CBD company could say whatever the hell he wants on the label and sell it to people.”
Cannabidiol is obtained from the flowers and buds of marijuana or hemp plants. It can not produce intoxication; marijuana’s “high” is due to the chemical tetrahydrocannabinol (THC). CBD oil is legal in 30 states where medicinal or recreational marijuana is legal, according to Governing magazine.
Seventeen additional states have CBD-specific laws on the books, in accordance with Prevention magazine. Those are Alabama, Georgia, Indiana, Iowa, Kentucky, Mississippi, Missouri, North Carolina, Oklahoma, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Wisconsin and Wyoming.
Strong Evidence for Treating Epilepsy – Just one single purported use for find more at healthbenefitscannabidiol.com, to treat epilepsy, has significant scientific evidence supporting it. Last month, a U.S. Food and Drug Administration advisory panel unanimously recommended approval from the CBD medication Epidiolex to take care of two rare forms of childhood epilepsy. “That’s truly the only area where evidence has risen to the level in which the FDA has said this is acceptable to approve a whole new drug,” said Timothy Welty, chair from the department of clinical sciences at Drake University’s College of Pharmacy and Health Sciences, in Des Moines, Iowa.
Throughout CBD’s potential uses, there exists simply too little evidence to produce a firm conclusion. For example, some human clinical trials advise that CBD may be good at treating symptoms of anxiety, particularly social anxiety, Bonn-Miller said. This is actually the potential use for CBD with the most evidence after usefulness in epilepsy, but “there’s a reliable gap between those two,” he said. “There has been clinical trials in adults, but a great deal small compared to the epilepsy studies that have been carried out in kids,” Bonn-Miller said. CBD’s usefulness as an anti-inflammatory medicine is the next most promising, but those results come mostly from animal studies, experts said.
The Majority Of Uses Largely Unproven – The remainder of the potential uses — being an antipsychotic, antidepressant or sleep aid “have all been studied in animals, with only 1 or 2 types of studies in humans,” Bonn-Miller said. And Welty said the studies who have featured humans for such other CBD uses have either been case reports or studies that failed to compare results against a control group that failed to use the oil. “There’s no control, so it’s basically how do you know if we’re dealing with the true effect in the drug or simply simply a placebo effect because somebody thinks they’ve been given a drug that will be beneficial?” Welty said. There are concerns about both the standard of CBD oil being produced and its potential side effects, professionals added.
Insufficient Regulation Also Concerning – As a result of legally murky nature of marijuana, the FDA has not stepped into regulate items like CBD oil, Bonn-Miller said. States are struggling to put regulations in position, however they don’t hold the deep pockets of the federal government. Meanwhile, a 2017 study led by Bonn-Miller found that nearly 7 of 10 CBD products didn’t contain the volume of marijuana extract promised on the label. Nearly 43 percent in the products contained inadequate CBD, while about 26 percent cptgdg excessive, Bonn-Miller said.
“CBD is type of a tricky drug because it’s not so well absorbed orally,” Welty explained. “Lower than 20 percent in the drug is absorbed orally. If this isn’t made in the right way, you might not receive much drug in your systemic circulation.” Worse, about 1 in 5 CBD products contained the intoxicating pot chemical THC, Bonn-Miller along with his colleagues found.
“That’s a difficulty because THC can increase anxiety. It may can even make seizures worse. Those are the sorts of things you have to be careful about,” Bonn-Miller said. “Basically If I were a consumer, purchasing it personally or my kid, I may wish to test it so that I knew what it actually had inside it, because I couldn’t trust what was on the label,” Bonn-Miller concluded.
Potential Interactions With Other Meds – Studies on CBD likewise have raised concerns about possible interactions with other drugs. For instance, epilepsy studies found that “there have been very clearly increases inside the blood amounts of some other anti-epileptic drugs when people were on CBD,” Welty said.